Sildenafil 50 Mg Film-coated Tablets

Patients should be advised that in case of sudden visual defect, he should stop taking Sildenafil tablets and consult a physician immediately see section 4. Based on efficacy and toleration, the dose may be increased to sildenafil mg and mg. Hypersensitivity to the active substance or to any of the excipients listed in section 6. Posology Use in adults: To email a medicine you must sign up and log in. Active ingredient sildenafil citrate. If Sildenafil is taken with food, the onset of activity may be delayed compared to the sildenafil state see Section 5. Using mg sildenafil tablets for a 50mg dose mg sildenafil tablets can also be convenient when used as 50mg tablets, meaning you can obtain m higher dose even if your initial prescription is only for 50mg. Based on efficacy andtolerability, the dose may be increased step-wise to 50mg and mg as necessary. In the natural setting, i. Initiation of sildenafil at a dose of 25 mg should be considered see section 4. Blue, almond shaped, biconvex, film coated tablets, debossed with '50' on one side and plain on other side. You should never alter the dosage of your sildenafil without talking to your doctor. The following patient groups were represented: Sildenafil potentiates the gm effect of nitrates see Section 4. Effects of sildenafil on other medicinal products In vitro studies: Use in patients using other medicines: Film-coated tablet White to off-white, round 9. Silenafil juice is a weak inhibitor of CYP3A4 gut wall metabolism and may give rise to modest increases in plasma levels of sildenafil. Treatment of men with erectile dysfunction, which is the inability to achieve or maintain a penile erection sufficient for satisfactory sexual performance. Method of administration For oral use. Paediatric population The European Medicines Agency has waived the obligation to submit the results of studies with Sildenafil in all subsets of the paediatric population for sildenafil treatment of erectile dysfunction.

These reports included dizziness and light-headedness, sildenafil not syncope. The results demonstrated no slidenafil relevant differences between sildenafil and placebo in time to limiting angina. Pharmacokinetic parameters of drugs give evidence to the high absorption. Sildenafil has a peripheral site of action on erections. G04B E See 4. Advantages of Viagra 1. In order to understand how Viagra works the mechanism of erection appearance and preventing factors should be examined. Many events were reported to occur during or shortly after sexual intercourse and a few were reported to occur shortly after the use of Sildenafil sildenafip without sexual activity. Company mb details Accord Healthcare Limited. Marketing authorisation number s 9. The mg tablets from Dr. If you are using sildenafil for the first time, it is very likely that you will be prescribed this dosage. The corresponding additional reduction in supine diastolic blood pressure was 7 mmHg. The most commonly reported adverse reactions in clinical studies among sildenafil treated patients were headache, flushing, dyspepsia, nasal congestion, dizziness, nausea, hot flush, visual disturbance, cyanopsia and blurred vision. The safety profile sildenafl Sildenafil wildenafil based on sildenafil in 74 double-blind placebo-controlled clinical studies. Studies with human platelets indicate that sildenafil potentiates the antiaggregatory effect of sodium nitroprusside in vitro. In the event of an erection that persists for longer than 4 hours, the patient should seek immediate sildenafil assistance. Throat tightness, Nasal oedema, Nasal dryness.

Dry eye, Lacrimal disorder and Lacrimation increased. The mean maximum decreases in supine systolic blood pressure following mg oral dosing of sildenafil was 8. In sildenafil to understand how Viagra works the mechanism of erection appearance and preventing factors should be examined. Pooling of the following classes of antihypertensive medication; diuretics, beta-blockers, ACE inhibitors, angiotensin II antagonists, antihypertensive medicinal products vasodilator and centrally-actingadrenergic neurone blockers, calcium channel blockers and alpha-adrenoceptor blockers, showed no difference in the side effect profile in patients taking sildenafil compared sildenafil placebo treatment. Using this site sets cookies - our Cookies Policy. Doses of mg did not result in increased efficacy but the incidence of adverse reactions headache, flushing, dizziness, dyspepsia, nasal congestion, altered vision was increased. Use in patients taking other medicinal products With the exception of ritonavir for which co-administration with sildenafil is not advised see Section 4. In three specific drug-drug interaction studies, the alpha-blocker doxazosin 4 mg and 8 mg and sildenafil 25 mg, 50 mg, or mg were administered simultaneously to patients with benign prostatic hyperplasia BPH stabilized on doxazosin therapy. No studies on the effects on the ability to drive and use machines have been performed. In a study of healthy male volunteers, co-administration of the endothelin antagonist, bosentan, an inducer of CYP3A4 [moderate], CYP2C9 and possibly of CYP2C19 at steady state mg twice a day with sildenafil at steady state 80 mg three times a day resulted in Sildenafil is an oral therapy for erectile dysfunction. No significant interactions were shown when sildenafil 50 mg was co-administered with tolbutamide mg or warfarin 40 mg50 mg sildenafil, both of which are metabolised by CYP2C9. There was no effect on sperm motility or morphology after single mg oral doses of sildenafil in healthy volunteers see section 4. Although no increased incidence of adverse events was observed in these patients, when sildenafil is administered concomitantly with Sildenafil inhibitors, a starting dose of 25mg should be considered. Cases of visual defects have been reported spontaneously in connection with the intake of sildenafil and other PDE5 inhibitors see section 4. At maximum recommended doses, there is an fold selectivity over PDE1, and over fold over PDE2, 3, 4, 7, 8, 9, 10 and Further information on clinical trials In clinical trials sildenafil was administered to more than patients aged These reports included dizziness and light-headedness, but not syncope. Therefore sexual stimulation is required in sildenafil for sildenafil to produce its intended beneficial pharmacological effects. The N-desmethyl metabolite is further metabolised, with a terminal half-life of approximately 4 h. There was no effect on sperm motility or morphology after single mg oral doses of sildenafil in healthy volunteers see section 5.

If Sildenafil tablets is taken with food, the onset of activity may be delayed compared to the fasted state see section 5. This is consistent sildenafil ritonavir's marked effects on a broad range of P substrates. Sildenafil Accord is also available as 25 mg tablets. The physiological mechanism responsible for erection of the penis involves the release of nitric oxide NO in the corpus cavernosum during sexual stimulation. Concomitant administration of sildenafil to patients taking alpha-blocker therapy may sildenafil to symptomatic hypotension in a few susceptible individuals. Gastro oesophageal reflux disease, Vomiting, Abdominal pain upper, Dry mouth. In average, it is needed about an hour to reach a peak content of sildenafil. Eildenafil each frequency grouping, 50 mg sildenafil, undesirable effects are presented in order of sildenafi seriousness. Studies with human platelets indicate that sildenafil potentiates the antiaggregatory effect of sodium nitroprusside in vitro. The major circulating metabolite results from N-demethylation of sildenafil. Sildenafil mg, 50mg, and 25mg available from Dr Fox online doctor and pharmacy from 97p each. Sildenafll use with alpha-blockers Caution is advised silvenafil sildenafil is administered to patients taking an alpha-blocker, as the coadministration may lead to symptomatic hypotension in a few susceptible individuals see section 4. Practically does not have side effects at all the positive effects for sexual life. Sildenafil is not indicated for use by women. Studies with human platelets indicate that sildenafil potentiates the antiaggregatory effect of sodium nitroprusside in vitro. Nicorandil is a hybrid of potassium channel activator and nitrate. Serious cardiovascular events, including myocardial infarction, unstable angina, sudden cardiac death, ventricular arrhythmia, cerebrovascular haemorrhage, transient ischaemic attack, my and hypotension have been reported post-marketing in temporal association with the use of Sildenafil. When sildenafil and doxazosin were administered simultaneously to patients stabilized on doxazosin therapy, there were infrequent reports of patients who experienced symptomatic postural silrenafil. The safety profile of Sildanafil is based suldenafil patients in 74 double blind placebo-controlled clinical studies. Concomitant use with other Sidenafil inhibitors or other treatments for erectile dysfunction The safety and efficacy of combinations of sildenafil with other PDE5 Inhibitors, or other pulmonary arterial hypertension PAH treatments containing sildenafil REVATIO50 mg sildenafil, other treatments for erectile dysfunction have not been studied. It is recommended that several attempts are made using the recommended starting dose before adjusting.

50 mg sildenafil

Thus during the arousal no physiological process does not prevent to occur the natural and normal erection. Clinical particulars 4. The following patient groups were represented: White to off-white, round 9. In the natural setting, i. Population pharmacokinetic analysis of clinical trial data indicated a reduction in sildenafil clearance when co-administered with CYP3A4 inhibitors such as ketoconazole, erythromycin, cimetidine. Further information on clinical trials In clinical trials sildenafil was administered to more than patients aged Concomitant use with alpha-blockers Caution is advised when sildenafil is administered to patients taking an alpha-blocker, as the coadministration may lead to symptomatic hypotension in a few susceptible individuals see section 4. Because not all adverse reactions are reported to the Marketing Authorisation Holder and included in the safety database, the frequencies of these reactions cannot be reliably determined. Pharmacological action of Viagra What is the process of erection? In single dose volunteer studies of doses up to mg, adverse reactions were similar to those seen at lower doses, but the incidence rates and severities were increased. Hepatic insufficiency: Last updated on eMC: Method of administration For oral use. Qualitative and quantitative composition 3. It is not recommended to take the tablet in a state of alcoholic inebriation — in this case even a small dose of alcohol can be harmful for blood circulation in the pelvic organs and sildenafil will not have the desired effect. The most commonly reported adverse reactions in clinical studies among sildenafil treated patients were headache, flushing, dyspepsia, nasal congestion, dizziness, nausea, hot flush, visual disturbance, cyanopsia and blurred vision. Sildenafil mg, 50mg, and 25mg available from Dr Fox online doctor and pharmacy from 97p each. Cardiovascular risk factors Prior sildenafil initiating any treatment for erectile dysfunction, physicians should consider the cardiovascular status of their patients, since there is a degree of cardiac risk associated with sexual activity. There are no data on the interaction sildenafil sildenafil and non-specific phosphodiesterase inhibitors such as theophylline or dipyridamole. They will probably encourage you to try it a few more times before you move onto something else. Use in patients with impaired hepatic function:

The pharmacokinetics of sildenafil in patients with severely impaired hepatic function have not been studied, 50 mg sildenafil. Although specific interaction studies were not conducted for all medicinal products, population pharmacokinetic analysis showed no effect of concomitant treatment on sildenafil pharmacokinetics when grouped as CYP2C9 inhibitors such as tolbutamide, warfarin, phenytoinCYP2D6 inhibitors such as selective serotonin reuptake inhibitors, tricyclic antidepressantsthiazide and related diuretics, loop and potassium sparing diuretics, angiotensin converting enzyme inhibitors, calcium channel blockers, beta-adrenoreceptor antagonists or inducers of Sildenafil metabolism such as rifampicin, barbiturates. Prescription only medicine. Sildenqfil isoenzymes it influences ten times less, i. Further information on clinical trials In clinical trials sildenafil was administered to more than patients aged Using mg sildenafil tablets for a 50mg dose mg sildenafil tablets can also be convenient when used as 50mg tablets, meaning you can obtain the higher dose even if your initial prescription is only for 50mg. These reports included dizziness and light-headedness, but not syncope. Tabulated list of adverse reactions. Sildenafil causes mild and transient decreases in blood pressure which, in the majority of cases, do not translate into clinical effects. The recommended sildsnafil is 50mg taken as needed approximately one hour before sexual activity. However, due to high inter-subject variability, these differences were not statistically significant. No relevant adverse effects were found in reproduction studies in rats and rabbits following oral administration of sildenafil. Stronger Sildenafil inhibitors such as ketoconazole and itraconazole would be expected to have greater effects. ATC Sildneafil This medicinal product does not require any special storage conditions. Tablet core: Reproductive system and breast disorders. The combination with fatty food will worsen the absorption and delay the onset of action of the drug. When sildenafil and doxazosin were administered simultaneously to patients stabilized on doxazosin therapy, there were infrequent reports of patients who experienced symptomatic postural hypotension. Pharmacological properties 5.

In single dose volunteer studies of doses up silsenafil mg, adverse reactions were similar to those seen at lower doses, but the incidence rates and severities were increased. Our Blog. Effects on vision Cases of visual defects have been reported spontaneously in connection with the intake of sildenafil and other PDE5 inhibitors see mv 4. Concomitant use with other PDE5 inhibitors or other treatments sildenavil erectile dysfunction The safety and efficacy of combinations of sildenafil with other PDE5 Inhibitors, or other pulmonary arterial hypertension PAH treatments containing sildenafil REVATIOother treatments for erectile dysfunction have not been studied. Marketing authorisation holder 8. Contraindications ager under 18 years old sildenafil hypersensivity to sildenafil and inactive ingredients regular or periodic use of drugs containing nitrates or nitrites. Blister pack: The contradictions for Viagra take are the following diseases: Date of revision of the text. The recommended dose is 50mg sildenacil as needed approximately one hour before sexual activity. Does not affect the quality of the sjldenafil and may be taken before planned conception. It is prescribed with caution to persons with the penis deformation, as well as with diseases of the circulatory system and predisposition to priapism. Sildenafil at 50 mg or mg significantly improved erection quality, treatment satisfaction, anxiety levels, and the sexual experience compared with placebo during DBPC. Cases of non-arteritic anterior ischaemic optic neuropathy, a silenafil condition, have been reported spontaneously and in an observational study in connection with the intake of sildenafil and other PDE5 inhibitors see section 4. According to statistics, about million men from 18 years and older suffer from problems in sexual life and urination due to the disorder of blood circulation in the pelvic. A double-blind, placebo-controlled exercise stress trial evaluated patients with erectile dysfunction and chronic stable angina who regularly received anti-anginal medicinal products except nitrates. It is prohibited to take with alcohol and drugs sildenafil organic nitrates. Visit Lloydspharmacy. After oral dosing of sildenafil AUC and C max increase in proportion with dose over the recommended dose range mg. The major circulating metabolite results from N-demethylation of sildenafil. In cases of overdose, standard supportive measures should sildenail adopted as required. The safety and efficacy of sildenafil was maintained in long term studies. Thanks to a big advertising campaign and truly innovative sikdenafil, the drug is known all over the world. Sildenafil Accord 50 mg Film-coated Tablets, 50 mg sildenafil. Two clinical studies were specifically designed to assess the time window after dosing during which sildenafil could produce an erection in response to sexual stimulation.

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Tablet core: Reporting suspected adverse reactions after authorisation of the medicinal product is important. Therefore sexual stimulation is required in order for sildenafil to produce its intended beneficial pharmacological effects. Use in patients with impaired renal function: Legal Category POM: It is recommended that several attempts are made using the recommended starting dose before adjusting. Your first prescription will usually be for 50mg, which is the recommended starting dose. Medically important adverse reactions reported at an incidence greater than placebo in controlled clinical studies and medically important adverse reactions reported sildenafil post-marketing surveillance. Pharmaceutical particulars 6. If, however, you find that sildenafil 50mg does not work for you the first time you take it, there are a few things you can do: Throat tightness, Nasal oedema, Nasal dryness. Therefore, inhibitors of these isoenzymes may reduce sildenafil clearance and inducers of these isoenzymes may increase sildenafil clearance. Protein binding is independent of total sildenafil concentrations. The results demonstrated no clinically relevant differences between sildenafil and placebo in time to limiting angina. Because not all adverse reactions are reported to the Marketing Authorisation Holder and included in the safety database, the frequencies of these reactions cannot be reliably determined, 50 mg sildenafil. In a separate RigiScan study, sildenafil was still able to produce an erection in response to sexual stimulation hours post-dose. Agents for the treatment of erectile dysfunction, including sildenafil, should not be used in men for whom sexual activity is inadvisable e. The most commonly prescribed sildenafil dosage is 50mg. Pharmacological properties 5. Urologicals; Drugs used in erectile dysfunction.

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When successful the effects of sildenafil 50mg should last for 4 to 6 hours; during this time, you should be able to attain an erection whenever you become sexually aroused. Practically does not have side effects at all the positive effects for sexual life. This information is intended for use by health professionals. Your first prescription will usually be for 50mg, which is the recommended starting dose. Excipient with known effect: This is most likely to occur within 4 hours post sildenafil dosing. The pharmacokinetics of sildenafil in patients with severely impaired hepatic function have not been studied. Blister pack: Sildenafil metabolism is principally mediated by the cytochrome P CYP isoforms 3A4 major route and 2C9 minor route. Clinical efficacy and safety Two clinical studies were specifically designed to assess the time window after dosing during which sildenafil could produce an erection in response to sexual stimulation. There was no effect on sperm motility or morphology after single mg oral doses of sildenafil in healthy volunteers see section 4. As dizziness and altered vision were reported in clinical trials with sildenafil, patients should be aware of how they react to Sildenafil tablets, before driving or operating machinery. Hypersensitivity to the active substance or to any of the excipients in sildenafil tablets see section 6. In a study of healthy male volunteers, co-administration of the endothelin antagonist, bosentan, an inducer of CYP3A4 [moderate], CYP2C9 and possibly of CYP2C19 at steady state mg twice a day with sildenafil at steady state 80 mg three times a day resulted in In normal healthy male volunteers, there was no evidence of an effect of azithromycin mg daily for 3 days on the AUC, Cmax, Tmax, elimination rate constant, or subsequent half-life of sildenafil or its principal circulating metabolite. Sildenafil tablets should not be administered to men with rare hereditary problems of galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption. Therefore sexual stimulation is required in order for sildenafil to produce its intended beneficial pharmacological effects.

In clinical trials sildenafil was administered to more than patients aged In a study of healthy male volunteers, co-administration of the endothelin antagonist, bosentan, an inducer of CYP3A4 [moderate], CYP2C9 and possibly of CYP2C19 at steady state mg twice a day with sildenafil at steady state 80 mg three times a day resulted in Calculation of dosage The drug is taken continuously or once. No relevant adverse effects were found in reproduction studies in rats and rabbits following oral administration of sildenafil. The safety of sildenafil has not been studied in the following sub-groups of patients and its use is therefore contraindicated: Grapefruit juice is a weak inhibitor of CYP3A4 gut wall metabolism and may give rise to modest increases in plasma levels of sildenafil. Allows to get rid of impotence even in complex cases. There are no adequate and well-controlled studies in pregnant or breast-feeding women. Cardiovascular risk factors Prior to initiating any treatment for erectile dysfunction, physicians should consider the cardiovascular status of their patients, since there is a degree of cardiac risk associated with sexual activity. There is a fold selectivity over PDE6 which is involved in the phototransduction pathway in the retina. These decreases in blood pressure are consistent with the vasodilatory effects of sildenafil, probably due to increased cGMP levels in vascular smooth muscle. There was no effect on sperm motility or morphology after single mg oral doses of sidenafil in healthy volunteers see section 5. Paediatric population Sildenafil is not indicated for individuals below 18 years of age. Gastro oesophageal reflux disease, Vomiting, Abdominal pain upper, Dry mouth. Healthcare professionals are asked to report any suspected adverse reactions via the Yellow Card Scheme at: When sildenafil and doxazosin were administered simultaneously to patients stabilized on doxazosin therapy, there were infrequent reports of patients who experienced symptomatic postural hypotension. There is no safety information on the administration of sildenafil to patients with bleeding disorders or active peptic ulceration. Today there are not less popular counterparts, and namely, German Levitra, American Cialis and other, but nevertheless, sildenafil keeps its position. Customer Services: What is the process of erection? The mean steady state volume of distribution Vd for sildenafil is l, indicating distribution into the tissues. Healthcare professionals are asked to report any suspected adverse reactions via Yellow Card Scheme Website: No studies on the effects on the ability to drive and use machines have been performed. A double-blind, placebo-controlled exercise stress trial evaluated patients with erectile dysfunction and chronic stable angina who regularly received anti-anginal medicinal products except nitrates. This is most likely to occur within 4 hours post sildenafil dosing. Sildenafil is contraindicated in patients who have loss of vision in one eye because of non-arteritic anterior ischaemic optic neuropathy NAIONregardless of whether this episode was in connection or not with previous PDE5 inhibitor exposure see section 4.

Medical Emergency. Active ingredient sildenafil citrate. Sildenafil had no effect on ritonavir pharmacokinetics. Sildenafil had no effect on saquinavir pharmacokinetics see section 4. In three specific drug-drug interaction studies, the alpha-blocker doxazosin 4 mg and 8 mg and sildenafil 25 mg, 50 mg, or mg were administered simultaneously to patients with benign prostatic hyperplasia BPH stabilized on doxazosin therapy. The safety of sildenafil has not been studied in the following sub-groups of patients and its use is therefore contraindicated: For the full list of excipients, see section 6. The European Medicines Agency has waived the obligation to submit the results of studies with Sildenafil in all subsets of the paediatric population for the treatment of erectile dysfunction. In vivo studies: You should never alter the dosage of your sildenafil without talking to your doctor. Pharmaceutical form 4. Renal dialysis is not expected to accelerate clearance as sildenafil is highly bound to plasma proteins and not eliminated in the urine. Patients should be advised that in case of sudden visual defect, he should stop taking Sildenafil tablets and consult a physician immediately see section 4. This uncertainty can lead to a great deal of anxiety for couples who have already had to deal with the frustration of erectile dysfunction — not knowing if they should again get their hopes up for a successful sexual encounter only to be disappointed. Calculation of dosage depends on many factors. Advantages of Viagra 1. But, if well tolerated and only mediocre results are reported, men are then often upgraded to sildenafil mg. The physiological mechanism responsible for erection of the sildeanfil involves the release of nitric oxide NO in the corpus cavernosum during sexual stimulation. Many events were reported to occur during or shortly after sexual intercourse and a few were reported to occur shortly after the use of Sildenafil without sexual activity. Preclinical studies showed additive systemic blood pressure sildehafil effect when PDE5 inhibitors were combined with riociguat. Based on efficacy and tolerability, the dose may be increased step-wise to 50mg and mg as necessary. In a study of healthy male volunteers, co-administration of the endothelin antagonist, bosentan, an inducer of CYP3A4 [moderate], CYP2C9 and possibly of CYP2C19 at steady state mg twice a day with sildenafil at steady state 80 mg three times a day resulted in This information sildenafil intended for use by health professionals. Agents for the treatment of erectile dysfunction, including sildenafil, should not be used in men for whom sexual activity is inadvisable e.