Caverject 20 Micrograms Powder For Solution For Injection

Instructions for use To perform the reconstitution, attach the needle to the device by pressing the needle onto the tip of the device and turning clockwise until it stops. Caverject is indicated for the treatment of erectile dysfunction in adult males due to neurogenic, vasculogenic, psychogenic or mixed aetiology. The treatment of priapism prolonged erection should not be delayed more than 6 hours. Predisposition to priapism eg, sickle cell anemia or trait, multiple myeloma, leukemia. Powder for solution for injection A white to off-white powder. Caverjet haemorrhage, Hypotension, Vasodilatation, Peripheral vascular disorder, caverjet, Vein disorder. They should remove the needle from the syringe, caverjet, discard it, and attach a new, unused sterile needle to the syringe. Reproductive System and Breast Disorders. Peripheral levels of the major circulating metabolite, oxo,dihydro-PGE 1increase to reach a peak 30 minutes after injection and return cavrjet pre-dose levels by 60 minutes after injection. As an aid to aetiologic diagnosis. Caverjet patients when using alprostadil should engage in sexual activity with caution. Treatment with alprostadil should be discontinued in patients who develop caverjet angulation, cavernosal fibrosis, or Peyronie's disease. Caverjet initial dose of alprostadil in patients with erectile dysfunction of neurogenic origin secondary to spinal cord injury is 1. Caverject is not intended to be mixed or coadministered with any other products. Should an ensuing erection persist for more caevrjet one hour detumescent therapy please refer to Section 4. Needle breakage, with a portion caverjey the needle remaining in the penis, has caveerjet reported and, in some cases, required hospitalisation and surgical removal. Blood creatinine increased, Blood pressure decreased, Heart cavegjet increased. The effects of combinations of alprostadil with other cavegjet for erectile dysfunction e. Erythema, Rash, Hyperhidrosis, Pruritus. Patients should be instructed to report to a physician any erection lasting for a prolonged time period, such as 4 hours or longer. Blood pressure and pulse should be continuously monitored during the procedure. At the time of discharge from the clinic, the erection should have subsided caverjet and the penis must be in a completely flaccid state. When reconstituted, each 1ml delivers a dose of 20 micrograms of alprostadil. Use of intracavernosal alprostadil offers no caverjet from the caverje of sexually transmitted diseases. Benzyl alcohol Water for injections.

The adverse drug reactions are listed in order of decreasing medical seriousness within each frequency category and system organ class. Sign Up Log In Cancel. Caverject should be used with care in patients who have experienced cavernet ischaemic attacks or those with unstable cardiovascular disorders. Alprostadil should be used with caution in patients who have experienced transient ischaemic attacks or those with unstable cardiovascular disorders. Painful erection is more likely to occur in patients with anatomical deformations of the penis, such as angulation, phimosis, cavernosal fibrosis, caverjet, Peyronie's disease or plaques. To view the changes to a medicine you must sign up and log in. The dose of Caverject should be individualised for each patient by careful titration under supervision by a physician. G04B E01 Alprostadil is present in various mammalian caverjet and fluids. Caerjet 1ml of cavdrjet solution contains 8. It is recommended that patients are regularly monitored e. These patients when using alprostadil should engage in sexual caverjer with caution. Extreme caution is required in patients with coronary heart disease, uncontrolled hypertension, cerebral ischaemia, and in subjects taking monoamine oxidase inhibitors, caverjet. General disorders and administration site conditions. Reporting suspected adverse reactions after authorisation of the medicinal product is important. Doses of greater than 60 micrograms of alprostadil are not recommended. As cavfrjet aid to aetiologic diagnosis. To bookmark a medicine caverjet must sign up and log in. The syringe and any remaining solution should be properly discarded. Blood creatinine increased, Blood caverjet decreased, Heart rate increased.

The dose that is selected for self-injection treatment should provide the patient with an erection that is satisfactory for sexual intercourse. Regular follow-up of patients, with careful examination of the penis, is strongly recommended to detect signs of penile fibrosis or Peyronie's disease. These patients when using alprostadil should engage in sexual activity with caution. Alprostadil Sterile Powder and solvent Dual Chamber contains benzyl alcohol, which may cause hypersensitivity reactions. As with all superfine needles, the possibility of needle breakage exists. Premature and low-birth weight infants may be more likely to develop toxicity. For erectile dysfunction of vasculogenic, psychogenic, or mixed aetiology, the initial dose is 2. It is recommended that the dose administered produces caverjet duration of the erection not exceeding one hour. If there caverjet a response, caverjet, there should be at least a 1-day interval before the next dose is given. Both the side of the penis that is injected and the site of injection must be alternated; prior to the injection, caverjet, the injection site must be cleansed with an alcohol swab. General Disorders and Administration Site Conditions. No formal studies with Caverject have been performed in patients younger than 18 years and older than 75 years. Careful patient instruction in proper handling and injection techniques may minimise the potential for needle breakage. At the time of discharge from the clinic, the erection should have subsided entirely and the penis must be in a completely flaccid state. Extreme caution is required in patients with coronary heart caverjet, uncontrolled hypertension, cerebral ischaemia, and in subjects taking monoamine oxidase inhibitors. Following intracavernous injection of 20 micrograms of alprostadil, mean peripheral levels of alprostadil at 30 and 60 minutes after injection are not significantly greater than baseline levels of endogenous PGE 1. Adjust volume to the required dose for injection. The first injections of alprostadil must be done by medically trained personnel. Caverjet reconstitute Caverject using the prefilled diluent syringe: The package insert provides full instructions on reconstitution, cleansing the injection site, and also how to perform the injection. No relevant information additional to that already contained in this SPC. Marketing authorisation holder 8. For erectile dysfunction of vasculogenic, psychogenic, or mixed aetiology, the initial dose is 2. Reproductive System and Breast Disorders. If still unsuccessful, intracavernous injection of alpha-adrenergic medication is recommended.

When reconstituted, each 1ml delivers a dose of 20 micrograms of alprostadil. Blood creatinine increased, Blood pressure decreased, Heart rate increased. The initial dose of alprostadil caverjet patients with erectile dysfunction of neurogenic origin secondary to spinal cord injury is 1. The site of injection is usually along the dorsolateral aspect of the proximal third of the penis. The metabolites are excreted primarily by the kidney and excretion is essentially complete within 24 hours. To minimize the risk, select the lowest effective dose, caverjet. If self-administration is planned, the physician should make an assessment of the patient's skill and competence with the procedure. Marketing authorisation holder 8. Painful erection is more likely to occur in patients with anatomical deformations of the penis, such as angulation, phimosis, cavernosal fibrosis, Peyronie's disease or plaques. The dose that is selected for self-injection treatment should provide the patient with an erection that is satisfactory for sexual intercourse. Alprostadil should be used with caution in patients caverjet cardiovascular and cerebrovascular risk factors. Effect of renal or hepatic impairment: Alprostadil is not caverjet for co-administration with any other agent for the treatment of erectile dysfunction see Section 4. Reconstituted solutions are intended for single use only, they should be used immediately and not stored. The intracavernosal injection must be done under sterile conditions.

Caverjet

The syringe and any remaining solution should be properly discarded. This may detumesce the penis. Therefore, a more consistent product delivery is produced caverjet Cverjet Water for Injection containing benzyl alcohol is used. If the duration is longer, the dose should be reduced. Caverjet to top Pfizer Limited contact details. Subscribe to receive email notifications whenever new articles are published. Last updated on eMC: Subjects with evidence of neurological dysfunction: Caverjet 1ml of reconstituted solution contains 8. The site of injection is usually along the dorsolateral aspect of the proximal third of the penis. Venous haemorrhage, Hypotension, Vasodilatation, Peripheral vascular disorder, Vein disorder. Alprostadil Sterile Powder and solvent Dual Chamber contains benzyl alcohol, which may cause hypersensitivity reactions. Treatment with alprostadil should be discontinued in patients who develop penile angulation, cavernosal fibrosis, or Peyronie's disease. The most frequent adverse reaction after intracavernosal injection of alprostadil is caverjdt pain. Initial therapy should be by penile aspiration. General Disorders and Administration Site Conditions. No relevant information additional to that already contained in this SPC.

Painful erection is more likely caverrjet occur in cavegjet with anatomical deformations of the penis, such as angulation, caverjet, phimosis, cavernosal fibrosis, Peyronie's disease or plaques. Skin and subcutaneous tissue disorders. Using aseptic caverjey, insert a gauge butterfly needle into the corpus cavernosum and aspirate ml of blood. Reporting caverjeh suspected adverse reactions Reporting suspected adverse reactions after authorisation of the medicinal product is important. In most animal species tested, caverjet relaxed retractor penis and corpus cavernosum urethrae in vitro. Treatment with Caverject Dual Chamber should be discontinued in patients who develop penile angulation, cavernosal fibrosis, or Peyronie's disease. Alprostadil caveejet enhance the effects of antihypertensives, vasodilative agents, anticoagulants and platelet aggregation inhibitors. Last updated on eMC: If self-administration is planned, the physician should make an assessment of the patient's skill and competence with the procedure. Marketing authorisation holder 8. Date of revision of the text. Patients with penile implants should not be treated with alprostadil. If necessary, the caverjet may be repeated on the opposite side of the penis until a total of up to ml blood has been aspirated. Following intracavernous injection of 20 micrograms of alprostadil, mean peripheral levels of alprostadil at 30 and 60 minutes after injection are not significantly greater than baseline levels of endogenous PGE 1. Show table of contents Hide table of contents 1. Following administration, any unused contents of the vial or syringe should be caverjet.

The pharmacotoxic signs of alprostadil are similar in all animal species and include depression, soft faverjet or diarrhoea and rapid breathing. Generic Name and Caverjet The first injections of alprostadil must be done by medically trained personnel. To investigate the effect of long-term intracavernosal self-injection of alprostadil Caverject on the penile circulation and return of spontaneous erection in men with arteriogenic erectile dysfunction. The dose that is selected for self-injection treatment should provide the patient with an erection that is satisfactory for sexual intercourse. The site of injection is usually along the dorsolateral aspect of the proximal cavermet of the penis. For the treatment of erectile dysfunction, caverjet, alprostadil is administered by injection into the corpora cavernosa. They should remove the needle from the syringe, discard it, and attach a caaverjet, unused sterile needle to the syringe. Also impotence has reportedly been caused by 16 of the most commonly prescribed drugs, including drugs for high blood pressure, caverjet, caverjet disease, and depression. Powder for solution for injection A white to off-white powder. Three per cent of patients discontinued treatment because of pain. Subsequent incremental increases of 5 - 10 micrograms should be given until an optimal dose is identified. To reconstitute Caverject using the prefilled diluent syringe: Alprostadil would not be expected to have an influence on the ability to drive or operate machines. Continue typing to refine. The adverse drug reactions are listed in order of decreasing medical seriousness within each frequency category and system organ class. Benzyl alcohol Water for injections. If this still fails to resolve the priapism, urgent surgical referral for further management, which may include a shunt procedure, is required. Venous haemorrhage, Hypotension, Vasodilatation, Peripheral vascular disorder, Vein disorder. Caverject is not intended to be mixed or coadministered with any other products. Reproductive system and caverjet disorders. Blood creatinine increased, Blood pressure decreased, Heart rate increased. Reporting of suspected adverse reactions Reporting suspected adverse reactions after authorisation of the medicinal product is important. Enter medicine name or company Start typing to retrieve search suggestions.

Reproductive system and breast disorders. Subsequent incremental increases of micrograms should be given until an optimal dose is achieved. Caverjet volume to the required dose for injection. If there is no response to the administered dose, then the next higher dose may be given within 1 hour. Call your doctor for medical advice about side effects. Erection usually occurs 5 to 15 minutes after injection. Excipients with known effect: Using aseptic technique, insert a gauge butterfly needle into the corpus cavernosum caverjet aspirate ml of blood. To bookmark a medicine you must sign up and log in. Caverject is not indicated for paediatric use see section 4. Caverject 20 micrograms powder for solution for injection. If the duration is longer, the dose should be reduced. Preclinical effects were observed only at exposures considered sufficiently in excess of the maximum human exposure indicating little relevance to clinical use. Eur, clear, borosilicate glass cartridges divided into two compartments and sealed with a bromobutyl rubber plunger. Alprostadil is present in various mammalian tissues and fluids. Initial therapy should be by penile aspiration. The dose caverjet is selected for self-injection treatment should provide the patient with an erection that is satisfactory for sexual intercourse, caverjet. Back to top Pfizer Limited contact details. Other side effects include bleeding at the injection site and an unhealthy, prolonged erection of four to six hours, caverjet. This information is intended caverjet use by health professionals. Sodium For the full list of excipients, see section 6. In contrast to keto-PGE 1 and keto,dihydro-PGE 1which lack almost completely biological activity, 13,dihydro-PGE caverjet has been shown to lower blood caverjet and inhibit platelet aggregation. Date of caverjet authorisation: Alprostadil caverjet enhance the effects of antihypertensives, vasodilative agents, anticoagulants and platelet aggregation inhibitors. To bookmark a medicine you must sign up and log in.

Active ingredient

Caverjet of intracavernosal alprostadil offers no protection from the transmission of sexually transmitted diseases. Injection site haematoma, Haematoma, Ecchymosis. For the treatment of erectile cavsrjet, alprostadil is administered by injection into the corpora cavernosa. Healthcare professionals are asked to report any suspected adverse reactions via the Yellow Card Scheme at www. As an aid to aetiologic diagnosis. Penile pain, prolonged erection, penile fibrosis, inj site hematoma or ecchymosis, penis disorder, penile rash or edema, other local effects, dizziness. Cavrejet necessary, the procedure may be repeated on caverjet opposite side of the penis until a total of up to ml blood has been aspirated. The risk of benzyl alcohol toxicity depends on csverjet quantity administered and the hepatic capacity to detoxify the chemical. Caverjet of revision of caerjet text. Visible veins should be avoided. Predisposition to priapism cavrjet, sickle cell anemia or trait, multiple myeloma, leukemia. Back to top Pfizer Limited contact details. Fit the 22 gauge needle to the syringe. The occurrence of fibrosis may increase with caverjet duration of caverejt. Regular follow-up of patients, with careful examination of the penis, is strongly recommended to detect signs of penile fibrosis or Peyronie's disease. The potential for abuse of alprostadil should be considered in patients with a history of psychiatric disorder or addiction. Musculoskeletal and Connective Tissue Disorders, caverjet. The presence of benzyl alcohol in the reconstitution vehicle decreases the degree of binding to package surfaces. Alprostadil would not be expected to have an influence on caverjet ability to drive or operate machines. Although the usual contra-indication to intrapenile administration of a vasoconstrictor does not apply in the treatment of priapism, caution is advised when this option is exercised. Venous haemorrhage, Hypotension, Vasodilatation, Peripheral vascular disorder, Vein disorder.

What do I need to tell my doctor BEFORE I take Caverject?

There is no evidence of tissue retention of alprostadil or its metabolites following intravenous administration. Visible veins should be avoided. Alprostadil is not intended for co-administration with any other agent for the treatment of erectile dysfunction see Section 4. Initial therapy should be by penile aspiration. Individuals who use alprostadil should be counselled about the protective measures that are necessary to guard against the spread of sexually transmitted diseases, including the human immunodeficiency virus HIV. High doses of alprostadil 0. The dose that is selected for self-injection treatment should provide the patient with an erection that is satisfactory for sexual intercourse. Reconstituted solutions are intended for single use only, they should be used immediately and not stored. Therefore, a more consistent product delivery is produced when Bacteriostatic Water for Injection containing benzyl alcohol is used. Blood creatinine increased, Blood pressure decreased, Heart rate increased. When reconstituted, each 1ml delivers a dose of 20 micrograms of alprostadil. When reconstituted, each 1ml delivers a dose of 20 micrograms of alprostadil. Sign Up Log In Cancel. Withdraw slightly more than the required dose of Caverject solution, remove the 22 gauge needle, and fit the 30 gauge needle. Although the usual contra-indication to intrapenile administration of a vasoconstrictor does not apply in the treatment of priapism, caution is advised when this option is exercised. Subjects without evidence of neurological dysfunction: Drugs used in erectile dysfunction ATC code: To reconstitute Caverject using the prefilled diluent syringe: Company contact details Pfizer Limited.

caverjet

The lowest effective dose should be used. Inject the 1 ml of diluent into the vial, and shake to dissolve the powder entirely. It has a diverse pharmacologic profile, among which some of its more important effects are vasodilation, inhibition of platelet aggregation, inhibition of gastric secretion, and stimulation of intestinal and uterine smooth muscle. Urethral haemorrhage, Haematuria, Dysuria, Pollakiuria, Micturition urgency. Alprostadil may enhance the effects of antihypertensives, vasodilative agents, anticoagulants and platelet aggregation inhibitors. Extreme caution is required in patients with coronary heart disease, uncontrolled hypertension, cerebral ischaemia, and in subjects taking monoamine oxidase inhibitors. The pharmacologic effect of alprostadil in the treatment of erectile dysfunction is presumed to be mediated by inhibition of alpha 1 -adrenergic activity in penile tissue and by its relaxing effect on cavernosal smooth muscle. The efficacy, tolerability, and return of spontaneous erections were assessed from the patients' diaries and by interview at each clinic visit. Powder and solvent for solution for injection Dual chamber glass cartridge containing a white lyophilised powder and diluent for reconstitution. Sodium For the full list of excipients, see section 6. Both the side of the penis that is injected and the site of injection must be alternated; prior to the injection, the injection site must be cleansed with an alcohol swab. Powder for solution for injection A white to off-white powder. Caverject Dual Chamber powder:. Its duration is dose dependent. Patients should be instructed to report immediately to a physician, or if unavailable to seek immediate medical assistance for any erection lasting for a prolonged time period, such as 4 hours. The site of injection is usually along the dorsolateral aspect of the proximal third of the penis. Patients on anticoagulants such as warfarin or heparin may have increased propensity for bleeding after the intracavernosal injection. At reconstitution, the complex is immediately dissociated into alprostadil and alfadex. Alprostadil should be used with caution in patients who have experienced transient ischaemic attacks or those with unstable cardiovascular disorders. It is recommended that the dose administered produces a duration of the erection not exceeding one hour. For the full list of excipients see section 6. The treatment of priapism prolonged erection should not be delayed more than 6 hours. Penile fibrosis, including angulation, cavernosal fibrosis, fibrotic nodules and Peyronie's disease may occur following the intracavernosal administration of alprostadil. Penile fibrotic conditions eg, anatomical deformation, angulation, cavernosal fibrosis, Peyronie's disease. The caverjet of Caverject should be individualised for each patient by careful titration under supervision by a physician. Back to top Pfizer Limited contact details.

Although the pharmacokinetics of alprostadil have not been formally examined in patients with renal or hepatic insufficiency, alterations in renal or hepatic function would not be expected to have a major influence on the pharmacokinetics of alprostadil. The lowest effective dose should be used. The usual maximum recommended frequency of injection is no more than once daily and no more than three times weekly. The occurrence of fibrosis may increase with increased duration of use. The intracavernosal injection must be done under sterile conditions. Sympathomimetics may reduce the effect of alprostadil. Caverject is indicated for the treatment of erectile dysfunction in adult males due to neurogenic, vasculogenic, psychogenic or mixed aetiology. Maintenance for home use: Following administration, any unused contents of the vial or syringe should be discarded. If self-administration is planned, the physician should make an assessment of the patient's skill and competence with the procedure. Adjust volume to the required dose for injection. If the duration is longer, the dose should be reduced. Refer to our editorial policy for content sources and attributions. Symptomatic treatment of any systemic symptoms would be appropriate. Company contact details Pfizer Limited. Symptomatic treatment of any systemic symptoms would be appropriate. The occurrence of fibrosis may increase with increased duration of use. Blood creatinine increased, Blood pressure decreased, Heart rate increased. Caverject is indicated for the caverjet of erectile dysfunction in adult males due to neurogenic, caerjet, psychogenic or mixed aetiology. Treatment with alprostadil should be discontinued in patients caverjet develop penile angulation, cavernosal fibrosis, or Peyronie's disease. Such agents should not be used in combination with alprostadil caverjet to the potential for inducing prolonged erections. Therefore, a more consistent product delivery is produced when Bacteriostatic Water for Injection containing benzyl alcohol is used. Reproductive System and Breast Disorders. Alprostadil should be used with caution in patients with cardiovascular and cerebrovascular risk factors. No relevant information additional cavfrjet that already contained in this SPC. Peripheral levels of the major circulating metabolite, oxo,dihydro-PGE 1 caverjet, increase to reach a peak 30 minutes after injection and return to pre-dose levels by 60 minutes after injection. Sexual stimulation and intercourse can lead to cardiac and pulmonary events in caverjet with coronary heart disease, congestive heart failure or pulmonary disease. Premature and low-birth weight infants may be more likely to develop toxicity.