Sildenafil, Oral Tablet

To view the changes to a medicine you must sign up and log in. Although specific interaction studies were not conducted for all medicinal products, population pharmacokinetic analysis showed no effect dose concomitant treatment on sildenafil pharmacokinetics when grouped as CYP2C9 inhibitors such as tolbutamide, warfarin, phenytoinCYP2D6 inhibitors such as selective serotonin reuptake inhibitors, tricyclic antidepressantsthiazide and related diuretics, loop and potassium sparing diuretics, angiotensin converting enzyme inhibitors, calcium channel blockers, beta-adrenoreceptor antagonists or inducers of CYP metabolism such as rifampicin, barbiturates. Your doctor may start you on a lowered dosage of sildenafil. Gastro oesophagael reflux disease, Vomiting, Abdominal pain upper, Dry mouth. Erectile dysfunction: Initiation of sildenafil at a dose of 25 mg should be considered see section 4. In clinical studies, riociguat has been shown to augment the hypotensive effects of PDE5 sildenafil. This site uses cookies. Ask your pharmacist for a list of the ingredients. Distribution The mean steady state volume of distribution V d for sildenafil is l, sildenafil dose, indicating distribution into the tissues. Absorption Sildenafil is rapidly absorbed. If you drink alcohol, talk to your doctor. Continue typing to refine. Other uses for this medicine. Erectile Dysfunction and Your Age: Concomitant use with alpha-blockers Caution is advised when sildenafil is administered to patients taking an alpha-blocker, as the co-administration may lead to symptomatic hypotension in a few susceptible individuals see section 4. Concomitant use with other PDE5 inhibitors or other treatments for erectile dysfunction. Reddy's Laboratories, Inc. Pharmaceutical form 4.

Active ingredient sildenafil citrate. Sildenafil had no effect on saquinavir pharmacokinetics see section 4. From worsening anxiety to making depression more likely, sugar is seriously harmful to your mental health. Subscribe to free Drugs. Sildenafil is contraindicated in patients who have loss of vision in one eye because of non-arteritic anterior ischaemic optic neuropathy NAIONregardless of whether this episode was in connection or not with previous PDE5 inhibitor exposure see section 4. Sildenafil citrate 50 mg is the recommended starting dose for men with erectile dysfunction ED ; however, sildenafil dose, most men are later titrated to sildenafil mg for improved efficacy. It appears unlikely that this drug will harm a pregnancy. In vivo studies: Sildenafil causes mild and transient decreases in sildenafil pressure which, in the majority of cases, do not translate into clinical effects. The easiest way to lookup drug information, identify pills, check interactions dose set sildenafil your own personal medication records. Sildenafil treats PAH by relaxing the blood vessels in the lungs to allow blood dose flow easily. This is because the amount of sildenafil in your body is increased. Brand names. Sildenafil does not prevent pregnancy or the spread of sexually transmitted diseases such as human immunodeficiency virus HIV. Many events were reported to occur during or shortly after sexual intercourse and a few were reported to occur shortly after the use of Sildenafil without sexual activity.

How should this medicine be used?

Although specific interaction studies were not conducted for sildenafil medicinal products, population pharmacokinetic analysis showed no effect of concomitant treatment on sildenafil pharmacokinetics when grouped as CYP2C9 inhibitors such as tolbutamide, warfarin, phenytoinCYP2D6 inhibitors such as selective serotonin reuptake inhibitors, tricyclic antidepressantsthiazide and related diuretics, loop and potassium sparing diuretics, angiotensin converting enzyme inhibitors, calcium channel blockers, beta-adrenoreceptor antagonists or inducers of CYP metabolism such as rifampicin, barbiturates. Many other medications may also interact with sildenafil, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list. Weekly news roundup. Sildenafil Viagra is used to treat erectile dysfunction impotence; inability to get or keep an erection in men. Taking sildenafil with certain medications raises your risk of side effects from these drugs. Marketing authorisation number s 9. Doses of mg did not result in increased efficacy but the incidence of adverse reactions headache, flushing, dizziness, dyspepsia, nasal congestion, altered vision was increased. This can happen if you are sick with dose, diarrhea, or vomiting; sweat a lot; or do not drink enough liquids. Pharmacological properties 5. Agents for the treatment of erectile dysfunction, including sildenafil, should be used with caution in patients with anatomical deformation of the penis such as angulation, cavernosal fibrosis or Peyronie's diseaseor in patients who have conditions which may predispose them to priapism dose as sickle cell sildenafil, multiple myeloma or leukaemia. There is no safety information on the sildenafil of sildenafil to patients with dose disorders or active peptic ulceration. Sildenafil metabolism is principally mediated by the cytochrome P CYP isoforms 3A4 major route and 2C9 minor route. Company contact details Pfizer Limited. For pregnant women: Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Prior to prescribing sildenafil, physicians should carefully consider whether their patients with certain underlying conditions could be adversely affected by such vasodilatory effects, especially in combination with sexual activity. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. What should I do if I forget a dose? If priapism is not treated immediately, penile tissue damage and permanent loss of potency could result. Pharmacokinetics in special patient groups. There was no evidence of favourable clinical effect of the combination in the population studied. Talk to your doctor about eating grapefruit and drinking grapefruit juice while taking this medicine. We comply with the HONcode standard for trustworthy health information - verify here. In addition, initiation of sildenafil at a dose of 25 mg should be considered see sections 4. Sildenafil 25 mg film-coated tablets Sildenafil 50 mg film-coated tablets Sildenafil mg film-coated tablets 2, sildenafil dose.

In three specific drug-drug interaction studies, the alpha-blocker doxazosin 4 mg and 8 mg and sildenafil 25 mg, 50 mg, or mg were administered simultaneously to patients with benign prostatic hyperplasia BPH stabilized on doxazosin therapy. In case of overdose, call the poison control helpline at The use of drinks that sildenafil alcohol raises your risk of low blood pressure from sildenafil. Hepatic impairment. Call your doctor right away if you have serious side effects. If you become pregnant while zildenafil sildenafil, call your doctor. It dose not known whether these events were caused by sildenafil, sexual activity, heart disease, or a combination of these and other causes. Healthline sildenafil made every effort to make certain that all information is factually correct, comprehensive, and up-to-date. Eat These 3 Things Instead. Taking sildenafil with certain medications dose your risk of side effects from sildenfil drugs. Lactose monohydrate 1 mg per 25 mg tablet 2 mg per 50 mg tablet 4 mg per mg tablet. Sildenafil treats erectile dysfunction by increasing blood flow to the penis during sexual stimulation. Availability Prescription only. Email Address. Available for Android and iOS devices. Musculoskeletal and connective tissue disorders.

Sildenafil dose

In single dose volunteer studies of doses up to mg, adverse reactions were similar to those seen at lower doses, but the incidence rates and severities were increased. In a study of healthy male volunteers, co-administration of the endothelin antagonist, bosentan, an inducer of CYP3A4 [moderate], Sildenafil and possibly of CYP2C19 at steady state mg twice a day with sildenafil at steady state 80 mg three times a day resulted in In vivo studies: Sildenafil has no direct relaxant effect on isolated human corpus cavernosum but potently enhances the relaxant effect of NO on this tissue. In the event of an erection that persists longer than 4 hours, the patient should seek immediate medical assistance. Although no increased incidence of adverse events was observed in sildenafil patients, when sildenafil is administered concomitantly with CYP3A4 inhibitors, a starting dose of 25 mg should be considered. Based on efficacy and tolerability, the dose may be increased step-wise to 50 mg up to mg as necessary, sildenafil dose. It is important to keep all medication out of sight and reach of children as many containers such as weekly pill minders and those for eye drops, creams, patches, and inhalers are not child-resistant and young children can open them dose. Date of revision of the dose. All rights reserved. Tell your doctor if sildenafil is not working well or if you are experiencing side effects. Medically important adverse reactions reported at an incidence greater than placebo in controlled clinical studies and medically important adverse reactions reported through post-marketing surveillance System Organ Class. The safety of sildenafil has not been studied in the following sub-groups of patients and its use is therefore contraindicated: Daily news summary. Based on these pharmacokinetic results co-administration of sildenafil with ritonavir is not advised see section 4. Side effects from sildenafil: Toggle navigation. If you become dose while taking sildenafil, call your doctor. Sildenafil oral tablet can interact with other medications, vitamins, or herbs sildenafil may be taking. For people with pulmonary veno-occlusive disease PVOD:

For people with heart problems: The corresponding additional reduction sildenafil sildenqfil diastolic blood pressure was 7 mmHg. If your symptoms are severe, call or go to the nearest emergency sildenafil right away. Active ingredient sildenafil citrate. For people with eye problems: The physiological mechanism responsible for erection of the penis involves the release of nitric dose NO in the corpus cavernosum during sexual stimulation. It is not known whether these events were caused by sildenafil, sexual activity, heart disease, or a combination of these and other causes. Search eMC: Availability Prescription only. Understanding Treatment Options, sildenafil dose. Hepatic impairment Since sildenafil clearance is reduced in patients with hepatic impairment e. Sildenafil Rating User Reviews 8. Some patients experienced a sudden loss of some or all of their vision after they took sildenafil or other medications silfenafil are similar to sildenafil. If you are taking sildenafil to treat erectile dysfunction, follow your doctor's directions and dose guidelines in this paragraph. Medications Used to Treat Erectile Dysfunction. In addition, initiation sildenafil sildenafil at a dose of 25 mg should be considered see sildenafi, 4. Microcrystalline cellulose Calcium hydrogen phosphate anhydrous Croscarmellose sodium Magnesium stearate Film coat: Sildennafil risk factors Prior to initiating any treatment for erectile dysfunction, physicians should consider the cardiovascular status of their patients, since there is a degree of cardiac risk associated with sexual activity. What other information should I know? Sildenafil showed sildenxfil effect on cardiac output, and did not impair blood flow through the stenosed coronary dose. Explore Apps.

Is It Inevitable? The major circulating metabolite results from N-demethylation sildenwfil sildenafil. Concomitant use with other PDE5 inhibitors or other treatments for erectile dysfunction. Table 1: For children: Concomitant use with ritonavir Co-administration of sildenafil with ritonavir is not advised see section 4. Concomitant use with alpha-blockers Caution is advised when sildenafil is administered to patients taking an alpha-blocker, sildenatil the co-administration may lead to symptomatic hypotension in a few susceptible individuals see section 4. Has not been studied. Sildenafil Rating User Reviews 8, sildenafil dose. Effect on bleeding Studies with human platelets isldenafil that sildenafil potentiates the antiaggregatory effect of sodium nitroprusside in vitro. Maximum observed plasma concentrations are reached within 30 to minutes median 60 minutes of oral dosing in the fasted state. Sildenafil belongs to a class sildenafi, drugs called phosphodiesterase type 5 PDE5 inhibitors. A double-blind, placebo-controlled exercise dose trial evaluated patients with erectile dysfunction and chronic stable angina who regularly received anti-anginal medicinal products except nitrates. The sildenafil of sildenafil in patients with severely impaired hepatic function have not been studied. If you have certain health conditions or are taking certain medications, your doctor may tell you to take sildenafil less often. Renal impairment. Available for Android and iOS devices. We comply with the HONcode standard for sildenafil health information - verify here. Talk eose your doctor about the risks of taking sildenafil.

For the full list of excipients, see section 6. Take as directed. Safety and efficacy have not been established in patients younger than 18 years. Revatio R: This information is intended for use by health professionals. Eat These 3 Things Instead. For people with eye problems: If priapism is not treated immediately, penile tissue damage and permanent loss of potency could result. In order to minimise the potential of developing postural hypotension in patients receiving alpha-blocker treatment, patients should be stabilised on alpha-blocker therapy prior to initiating sildenafil treatment. Patients should be advised that in the event of any sudden visual defect, they should stop taking Sildenafil and consult a physician immediately see section 4. Agents for pulmonary hypertension Impotence agents. Initiation of sildenafil at a dose of 25 mg should be considered see section 4. Available for Android and iOS devices. Call your doctor if you have any unusual problems while you are taking this medication. Preclinical studies showed additive systemic blood pressure lowering effect when PDE5 inhibitors were combined with riociguat. Tablet core: Sildenafil 25 mg film-coated tablets Sildenafil 50 mg film-coated tablets Sildenafil mg film-coated tablets. There was no effect on sperm motility or morphology after single mg oral doses of sildenafil in healthy volunteers see section 4.

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This information is intended for use by health professionals. Continue to take sildenafil even if you feel well. But if you're someone who wants to keep it simple and effective, then this workout routine is…. Drug Status Rx. The hearing loss usually involved only one ear and did not always improve when the medication was stopped. These reports included dizziness and light-headedness, but not syncope. Women Sildenafil is not indicated for use by women. You may assume the likelihood of erectile dysfunction increases with age, but this isn't always the case. Therefore the use of such combinations is not recommended. You may need to decide whether to stop breastfeeding or stop taking this medication. We comply with the HONcode standard for trustworthy health information - verify here. The film coating of the tablet contains lactose. The results demonstrated no clinically relevant differences between sildenafil and placebo in time to limiting angina. Tablet core: Effects of other medicinal products on sildenafil In vitro studies: It is not known whether these events were caused by sildenafil, sexual activity, heart disease, or a combination of these and other causes. Sildenafil pronounced as sil den' a fil.

sildenafil dose

Improvements in DBPC patient-reported outcomes from baseline were statistically significant for both sildenafil 50 and mg compared with placebo. Therefore the use of such combinations is not recommended. Mechanism of action. Safety and efficacy have not been established in patients younger than 18 years. What special precautions should I follow? Pulmonary hypertension is a progressive, quickly advancing disease. This drug can lower your blood pressure. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Sildenafil should not be administered to men with rare hereditary problems of galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption. The maximum recommended dosing frequency is once per day. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. Before taking sildenafil, tell your doctor and pharmacist if you are allergic to sildenafil, any other medications, or any of the ingredients in sildenafil products. This drug may cause sudden loss of vision in one or both eyes. Sildenafil is contraindicated in patients who have loss of vision in one eye because of non-arteritic anterior ischaemic optic neuropathy NAION , regardless of whether this episode was in connection or not with previous PDE5 inhibitor exposure see section 4. It appears unlikely that this drug will harm a pregnancy. Sildenafil is a prescription drug. If Sildenafil is taken with food, the onset of activity may be delayed compared to the fasted state see section 5. Medications Used to Treat Erectile Dysfunction. We comply with the HONcode standard for trustworthy health information - verify here, sildenafil dose. Always discuss possible dose effects with a healthcare provider who knows your medical history. Sildenafil may sildenafil side effects. Sildenafil pronounced as sil den' a fil. What special dietary instructions should I follow? Print this page Add to My Med List. Method of administration For oral use.

Drug Class. This can happen if you are sick with fever, diarrhea, or vomiting; sweat a lot; or do not drink enough liquids. Cases of visual defects have been reported spontaneously in connection with the intake of sildenafil and other PDE5 inhibitors see section 4. These additional blood pressure reductions were of a similar magnitude to those seen when sildenafil was administered alone to healthy volunteers see section 5. The film coating of the tablet contains lactose. Shake the liquid well for 10 seconds before each use to mix the medication evenly. In clinical studies, riociguat has been shown to augment the hypotensive effects of PDE5 inhibitors. Use in patients taking other medicinal products With the exception of ritonavir for which co-administration with sildenafil is not advised see section 4. Some patients experienced a sudden decrease or loss of hearing after they took sildenafil or other medications that are similar to sildenafil. The co-administration of PDE5 inhibitors, including sildenafil, with guanylate cyclase stimulators, such as riociguat, is contraindicated as it may potentially lead to symptomatic hypotension see section 4. Tell your doctor if sildenafil is not working well or if you are experiencing side effects. Brand names. Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up-to-date. If you are taking sildenafil for PAH, take the missed dose as soon as you remember it. Hypromellose Lactose monohydrate Triacetin Titanium dioxide E 6. There is a fold selectivity over PDE6 which is involved in the phototransduction pathway in the retina. After oral dosing of sildenafil AUC and C max increase in proportion with dose over the recommended dose range mg. Sildenafil Pfizer may have a minor influence on the ability to drive and use machines. Sildenafil should not be administered to men with rare hereditary problems of galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption. Sildenafil is in a class of medications called phosphodiesterase Dose inhibitors. Sildenafil is a prescription drug. You may need to have your blood pressure monitored while you take this drug. There is no safety information on the administration of sildenafil to patients with bleeding disorders or active peptic ulceration. General disorders and administration site conditions. Prior to initiating any treatment for erectile dysfunction, physicians should consider the cardiovascular status of their patients, since there is a degree of cardiac risk associated with sexual activity. Sildenafil Pfizer sildenafil have a minor influence on the ability to drive and use machines. If you experience a sudden loss of vision while you are taking sildenafil, call your doctor immediately.