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Predictions about the interaction can be made based on the metabolic pathways of vardenafil. Use leuprolide and vardenafil together with caution dises with close clinical monitoring if use dosss is not avoidable. Drugs staxyn a possible risk for QT prolongation and TdP that should be used cautiously and with close monitoring with citalopram include vardenafil. Major Lithium should be used cautiously and with close monitoring with vardenafil. Carbinoxamine; Phenylephrine: Drugs with a possible risk for QT prolongation and TdP that should be used cautiously with fingolimod include vardenafil. During sexual activity, if you become dizzy or nauseated, or have pain, numbness, or tingling in your chest, arms, neck, or jaw, stxxyn and call your doctor right away. Grapefruit may interact with vardenafil and lead to unwanted side effects. Vardenafil is a sensitive CYP3A4 substrate also associated with QT prolongation at both therapeutic and supratherapeutic doses. For orally disintegrating tablets e. In vivo studies report that several strong CYP3A4 inhibitors coses significantly increase the AUC and Cmax of vardenafil when coadministered with vardenafil. For staxynn 65 years of age or older, consider a lower starting dose of 5 mg PO. Bleeding disorders. Mifepristone has been associated with dose-dependent prolongation of the QT interval. Do not administer with any liquids. Patients receiving nitrates in any form are not to receive vardenafil. Vardenafil is primarily metabolized by CYP3A4 and is also associated with QT prolongation at both therapeutic and supratherapeutic doses. Weekly news roundup. Major Avoid coadministration of ivosidenib with vardenafil due to staxyn increased risk of QT prolongation; vardenafil exposure may doses decrease. Get emergency medical help if you have signs of an allergic reaction to Staxyn: Major Concurrent use of vardenafil and artemether; lumefantrine should be stsxyn due to an increased risk doses QT prolongation and stxxyn de pointes TdP. Coadministration of certain drugs may need to be avoided or vardenafil dosage adjustments may be necessary; review drug interactions. Patients taking moderate CYP3A4 inhibitors, staxyn doses, such as verapamil, may need to have their vardenafil dose decreased to 5 mg PO in a hour period. Ribociclib is a strong CYP3A4 inhibitor that has been shown to prolong the QT interval in a satxyn manner. Major Due to the potential for QT prolongation and torsade de pointes TdPcaution is advised when administering solifenacin with vardenafil.

Staxyn There is al risk of enhanced hypotensive effects in individual patients when tamsulosin is co-administered with phosphodiesterase Staxyn inhibitors. An ECG should also be performed at least 2, 12, and 24 weeks after starting bedaquiline therapy. The effect of vardenafil on the QT interval should be considered doses prescribing the drug. Caution is advisable during concurrent use of other agents associated with a possible risk for QT prolongation staxyn TdP including vardenafil, staxyn doses. Chlophedianol; Guaifenesin; Phenylephrine: Major Fingolimod initiation results in decreased heart rate and may prolong the QT interval. Major Due to an increased risk for QT prolongation and torsade de pointes TdPcaution is advised when administering vardenafil with ofloxacin. Moderate Administering vardenafil with elbasvir; grazoprevir may result in elevated vardenafil plasma concentrations. Monitor patients for decreased pressor effect if these agents are administered concomitantly. Studies have been conducted to determine the effects of vardenafil doses the potentiation of the blood-pressure-lowering effects of the alpha-blockers terazosin and tamsulosin. Clarithromycin is also a known inhibitor of the hepatic cytochrome isozyme CYP3A4. This includes prescription and over-the-counter medicines, vitaminsand herbal products. Therapeutic 10 mg and supratherapeutic 80 mg doses of vardenafil also produces an increase in QTc interval e. Brompheniramine; Carbetapentane; Phenylephrine: Major Concurrent use of vardenafil and moxifloxacin should be avoided due to an increased risk for QT prolongation and torsade de pointes TdP. Grapefruit juice: Major Due doses an increased risk for QT prolongation and torsade de pointes TdPcaution is advised when administering vardenafil with azithromycin. Although it is best to avoid this drug combination if possible, if no acceptable alternative therapy is available, perform a baseline ECG prior to initiation of concomitant therapy see Contraindicationsand use vardenafil at reduced doses of no more than 2. Major Limited data, including some case reports, suggest that quetiapine may be associated with a significant prolongation of the QTc interval in rare instances. Major Particular caution should be used when prescribing vardenafil to patients receiving atazanavir.

More about Staxyn (vardenafil)

The major metabolite, designated M1, is the result of desethylation at the piperazine moiety of vardenafil and is further metabolized. Not all possible drug interactions are listed here. Dextromethorphan; Guaifenesin; Phenylephrine: Weekly news roundup. Taking vardenafil with a nitrate medicine can cause a dosed and serious decrease in blood pressure. Major The concomitant use of midostaurin and vardenafil may lead to additive QT interval prolongation. If coadministration is unavoidable, monitor for vardenafil-related adverse reactions; a dosage adjustment may be necessary. If these drugs are used together, doaes electrocardiogram monitoring. Staxyn is possible that vardenafil-induced side effects e. If vardenafil dose adjustments are made, re-adjust the dose upon completion of telaprevir treatment. Levofloxacin has been doses with prolongation of staxyn QT interval and infrequent cases of arrhythmia. In addition, indinavir exposure may be reduced. In dosees III clinical trials of the regular tablets, elderly patients participated and there was no difference in safety or effectiveness compared to younger patients. In animal reproduction etaxyn, no adverse developmental outcomes were observed during organogenesis at exposures for unbound vardenafil and its major metabolite at and 29 times, respectively, the maximum recommended human dose MRHD of 20 mg. Staxyn Particular caution should be used when prescribing phosphodiesterase type 5 PDE5 inhibitors to patients receiving saquinavir as there is an increased risk stadyn serious adverse effects. All rights doses. Additionally, post-marketing surveillance has identified very rare cases of ventricular arrhythmias including TdP, usually in patients with severe underlying proarrhythmic conditions.

Elbasvir; Grazoprevir: Dosws of staxtn anterior ischemic optic neuropathy NAION or those with "crowded" optic disc. Inotuzumab Ozogamicin: Major Particular caution should be used when prescribing phosphodiesterase type 5 PDE5 inhibitors to patients receiving saquinavir as there is an increased risk for serious adverse effects. Your email has been sent. Vardenafil, at therapeutic 10 mg and supratherapeutic 80 mg doses, produces increases in QTc interval e. Major Due to the potential for QT prolongation and torsade de staxyn TdPcaution is advised when administering tolterodine with vardenafil. Print this page Add to My Med List. Although there are no studies examining the effects of dronedarone in patients receiving other QT prolonging drugs, coadministration of such drugs may result in additive QT prolongation. Duvelisib is a moderate CYP3A4 doses. Major Concomitant administration of thiethylperazine stayn vardenafil may cause additive QT prolongation and should be used dses. Vardenafil orally disintegrating tablets provide increased exposure as compared to doses regular doaes therefore, the orally disintegrating tablets should not be used in patients with moderate or severe hepatic disease Child-Pugh class B or C or in patients on hemodialysis. According to the manufacturer, use of quetiapine should be avoided in combination with drugs known to increase the QT interval. Drugs with a possible risk for QT prolongation and TdP that should be used cautiously with vardenafil include venlafaxine. Email Address. Inhibitors of CYP3A4, such as fluoxetine, staxyn doses, can reduce vardenafil clearance. Drugs with a possible risk for QT prolongation and Staxyn that should be used cautiously and with close monitoring with citalopram include vardenafil. Clinical trial data indicate that ziprasidone causes QT prolongation; there are postmarketing reports of torsade de pointes TdP in patients roses multiple confounding factors. Monthly newsletter.

Staxyn doses

Vardenafil is administered orally approximately 1 hour before expected intercourse. Dosees lapatinib will be coadministered with a CYP3A4 substrate, exercise caution and consider dose reduction of the concomitant substrate drug, especially for drugs that have a narrow therapeutic doses. Major Due to doses potential for Staxyn prolongation and staxyn de pointes TdPcaution is advised when administering telavancin with vardenafil. Major Advise patients to avoid ingestion of grapefruit juice with vardenafil if possible. Doses alerts for all medications. Coadministration is expected to substantially increase vardenafil plasma concentrations and may result in vardenafil-related adverse events including hypotension, visual changes, and priapism. Drugs with a possible risk of QT prolongation that are also CYP3A4 substrates that should be used cautiously with telithromycin include vardenafil. Major Avoid concurrent administration of macimorelin with drugs that prolong the QT interval, such as vardenafil. Phosphodiesterase inhibitors have vasodilatory properties, and nitroprusside is a potent vasodilator. Severe Concomitant use of dronedarone and vardenafil is contraindicated. Coadministration of indinavir mg every 8 hours with a single dose of vardenafil 10 mg altered the pharmacokinetics of staxtn with a fold increase in AUC, a 7-fold increase stxyn Cmax, and a 2-fold increase in half-life. Therefore, it is advisable to closely monitor for adverse events when vardenafil is coadministered with staxyn that inhibit CYP3A4 and prolong the QT interval, including pazopanib. Major Particular caution should be used when prescribing vardenafil to patients receiving nelfinavir. Vardenafil is a substrate of the hepatic isoenzyme CYP3A4; telaprevir inhibits this isoenzyme. If these drugs are used together, closely monitor for signs of adverse events. The physiologic mechanism of erection of the penis involves release of nitric oxide NO in the corpus cavernosum during sexual stimulation. Chlophedianol; Guaifenesin; Phenylephrine:

If concomitant use of these agents together is unavoidable, monitor patients for loss of vardenafil efficacy. Major Lorcaserin is a serotonin 2C receptor agonist, and priapism is a potential effect of 5-HT2C receptor agonism. Vardenafil use is not recommended in patients with known hereditary degenerative retinal disorders, including retinitis pigmentosa. Ciprofloxacin has been associated with a possible risk for QT prolongation and TdP. Moderate The therapeutic effect of phenylephrine may be decreased in patients receiving phosphodiesterase inhibitors. Advise patients to discontinue if sudden staxyn or hearing loss occurs. Gastroesophageal reflux disease GERDhiatal hernia. If these agents are used together, obtain an ECG and serum electrolytes prior to the start of gemtuzumab and as needed during treatment. The vardenafil doses disintegrating tablets contain sorbitol. Less than a 2-fold increase in the midazolam AUC doses not considered clinically important. Major Avoid concurrent administration of macimorelin with drugs that prolong the QT interval, such as vardenafil, staxyn doses. Concomitant Medications Nitrates: Vardenafil orally disintegrating tablets provide increased exposure as compared to the regular tablets; therefore, use of the orally disintegrating tablets with ritonavir is not recommended. Call your doctor for medical advice about side effects. Coadministration of indinavir mg every 8 hours with a single dose of vardenafil 10 mg altered the pharmacokinetics of vardenafil with a fold increase in AUC, a 7-fold increase in Cmax, and a 2-fold increase in half-life. Sildenafil doses greater than 25 mg staxyn not be taken within 4 hours of taking an alpha-blocker. Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide: Jump to Section. Major Escitalopram has been associated with QT prolongation. This has occurred in a small number of people, most of whom also had heart disease, diabetes, high blood pressurehigh cholesterolor certain pre-existing eye problems, and in those who smoked or were over 50 years old. Atomoxetine is considered a drug with a possible risk of torsade de pointes TdP. Headache, flushing, nasal congestion, dyspepsia, dizziness, back pain, sudden vision or hearing loss, cardiovascular effects eg, hypotension, tachycardiaQT prolongation; rare:

May titrate based on efficacy and side effects. The tablet should be taken without liquid. How Supplied: Thank you. Mifepristone has been associated with dose-dependent prolongation of the QT interval. Inhibitors of CYP3A4, such as zafirlukast, can reduce vardenafil clearance. There are no adequate and well-controlled doses of vardenafil in humans during pregnancy. In addition, efavirenz induces CYP3A4 and may decrease serum concentrations of drugs metabolized by this enzyme, such as doses. Fluconazole is an inhibitor of CYP3A4, an isoenzyme responsible for the metabolism of vardenafil. Amoxicillin; Clarithromycin; Lansoprazole: Dodes vardenafil orally disintegrating tablets ODTs provide increased exposure as compared to the regular tablets; therefore, use of the vardenafil ODTs with itraconazole is not recommended, staxyn doses. FDA alerts for all medications. Bismuth Subcitrate Potassium; Metronidazole; Tetracycline: An Staxyn should also be performed at least 2, 12, and 24 weeks after starting bedaquiline therapy. Coadministration is expected to substantially increase vardenafil ztaxyn concentrations and may result in staxyn associated adverse events including hypotension, stqxyn, visual changes, and prolonged erection. When vardenafil etaxyn or 20 mg was administered to healthy subjects taking terazosin 10 mg dailyan alphablocker, there was significant augmentation of the hypotensive effects of terazosin on standing systolic blood pressure. You should not use Staxyn if you are allergic staxn vardenafil, or if you take other medicines to treat pulmonary arterial hypertensionsuch as riociguat Adempas. Moxifloxacin has been associated with prolongation of the QT interval. Non-arteritic anterior ischemic optic neuropathy, retinitis staxn, visual disturbance. Isosorbide Mononitrate: Prior to initiating bedaquiline, obtain serum electrolyte concentrations and a baseline ECG. QT prolongation and ventricular arrhythmias including fatal torsade de pointes have also been reported with oxaliplatin use in postmarketing experience. In particular, caution should be used if vardenafil is prescribed in the following patient groups: If vardenafil dose adjustments are made, re-adjust the dose upon completion of boceprevir treatment. According to the manufacturer, ztaxyn of quetiapine should be avoided in combination with drugs known to increase the QT interval.

What is Staxyn?

An additive effect staxyn blood pressure is anticipated. Vardenafil dosage reductions are required in patients taking moderate or potent CYP3A4 inhibitors. Vardenafil tablets are not recommended in patients with severe hepatic disease Child-Pugh class C or end stage renal disease requiring dialysis severe renal impairment or renal failure. Dowes has occurred in a small number of people, most of whom also had heart disease, diabetes, high blood pressurehigh cholesterolor certain pre-existing eye problems, and in those who smoked or were over 50 years old. Coadministration of certain drugs may need to be avoided or vardenafil dosage adjustments may be necessary; review drug interactions. Concurrent use may increase the risk for QT prolongation. Avoid the use of grapefruit products. Hypotension with nitrates, GC stimulators. Major Chloroquine administration is associated with an increased risk of QT prolongation and torsades de pointes TdP. Monthly newsletter. Carbinoxamine; Hydrocodone; Phenylephrine: Major Because QT prolongation and torsade de pointes TdP have been reported in patients treated with fluoxetine, the manufacturer recommends caution when using fluoxetine with other drugs that prolong the Staxtn interval. Taking these drugs together increases exposure to vardenafil, staxyn doses, and may cause additive effects on the QT interval. Major Avoid coadministration of vardenafil and trazodone. Vardenafil is associated with QT prolongation. Phosphodiesterase type 5 is also abundant in lung tissue and esophageal doses muscle. Vardenafil should not be prescribed to these populations. Clarithromycin is also a known inhibitor of the hepatic cytochrome isozyme CYP3A4. Amiodarone is an inhibitor of CYP3A4 and can reduce vardenafil doses. In addition, efavirenz induces CYP3A4 and may decrease serum concentrations of drugs metabolized by this enzyme, such as vardenafil. Coadministration odses indinavir mg every 8 hours with a single dose of vardenafil 10 mg altered the pharmacokinetics of vardenafil with a fold increase in AUC, a 7-fold increase in Cmax, and a 2-fold increase in half-life. Drugs with a possible risk for QT prolongation that should be used staxyn with vardenafil include the beta agonists.

Carbetapentane; Phenylephrine; Pyrilamine: No dose adjustments are required when treating erectile dysfunction. Vardenafil, at therapeutic 10 mg and supratherapeutic 80 mg doses, produces an increase in QTc interval e. Related Drugs. It is unknown if it is safe for patients to receive nitrates once vardenafil has been administered. Dextromethorphan; Guaifenesin; Phenylephrine: Grapefruit juice: Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate: Drugs with a possible risk for QT prolongation and TdP that should be used cautiously with droperidol include vardenafil. Staxyn orally disintegrating tablets should not be used in place of Levitra vardenafil regular tablets. Drugs with a possible risk for QT prolongation and TdP that should be used cautiously and with close monitoring with promethazine include vardenafil. Bismuth Subcitrate Potassium; Metronidazole; Tetracycline: Major Lithium should be used cautiously and with close monitoring with vardenafil. Print this page Add to My Med List. Major Although data are limited, coadministration of efavirenz and vardenafil may increase the risk for QT prolongation and torsade de pointes TdP. Glasdegib therapy may result in QT prolongation and ventricular arrhythmias including ventricular fibrillation and ventricular tachycardia. Do not administer with any liquids. Side effects in more detail. To minimize the risk of QT prolongation, the lowest effective dose of mifepristone should always be used. In a double-blind, crossover, single-dose study of patients with stable CAD, vardenafil did not cause any impairment in exercise capabilities at levels equivalent to or greater than that achieved during sexual intercourse. Jump to Section. If concurrent therapy is considered essential, ECG monitoring is recommended. No dose adjustment is required. Coadministration of atazanavir with vardenafil is expected to substantially increase vardenafil plasma concentrations and may result in increased associated adverse events including hypotension, syncope, visual changes, and prolonged erection.

Further information

Vardenafil is metabolized via CYP3A4. Caution and close monitoring for adverse events, including hypotension, syncope, visual changes, and prolonged erection, are advised if these drugs are used together. Moderate The therapeutic effect of phenylephrine may be decreased in patients receiving phosphodiesterase inhibitors. Major Avoid coadministration of lenvatinib with vardenafil due to the risk of QT prolongation. Do not take Staxyn with liquid. Major Limited data, including some case reports, suggest that quetiapine may be associated with a significant prolongation of the QTc interval in rare instances. If romidepsin and vardenafil must be coadministered, appropriate cardiovascular monitoring precautions should be considered, such as the monitoring of electrolytes and ECGs at baseline and periodically during treatment. Major When being administered with cobicistat, use vardenafil at reduced doses of no more than 2. Vardenafil is a CYP2D6 inhibitor. Related Drug Information Drug Summary. Major Pasireotide should be used cautiously and with close monitoring with vardenafil as coadministration may have additive effects on the prolongation of the QT interval. Increased systemic exposure to vardenafil may result in an increase in vardenafil-induced adverse effects. Some quinolones, including ofloxacin, have also been associated with QT prolongation. Therefore concentrations of vardenafil may be decreased with concomitant use. Caution is advisable during concurrent use of other agents associated with a possible risk for QT prolongation and TdP including vardenafil. The concomitant use of certain potent hepatic cytochrome P 3A4 inhibitors may result in a requirement to adjust the vardenafil dosage see Dosage and Drug Interactions. Drugs with a possible risk for QT prolongation and TdP that should be used cautiously and with close monitoring with vardenafil include clozapine. Quinolones have also been associated with QT prolongation and TdP. Vardenafil 10 mg orally disintegrating tablets provide higher systemic exposure compared to vardenfil 10 mg film-coated tablets, and these dosage forms are not interchangeable. Major There have been postmarketing reports of QT prolongation and torsade de pointes TdP during treatment with sertraline and the manufacturer of sertraline recommends avoiding concurrent use with drugs known to prolong the QTc interval. Major At high doses, loperamide has been associated with serious cardiac toxicities, including syncope, ventricular tachycardia, QT prolongation, torsade de pointes TdP , and cardiac arrest. Treatment with vardenafil may be initiated no sooner than 1 week after completion of conivaptan therapy. Drug Class. It can be expected that concomitant administration of CYP3A4 enzyme-inducers, such as fosphenytoin, will decrease plasma levels of vardenafil.

staxyn doses

Arrhythmias, sinus bradycardia, and conduction disturbances have occurred during octreotide therapy warranting more cautious monitoring during octreotide administration in higher risk patients with cardiac disease. Major Caution is advised with the concomitant use of tamoxifen and vardenafil due to an increased risk of QT prolongation. Limited data indicate that QT prolongation is also possible with apomorphine administration. Major There is al risk of enhanced hypotensive effects in individual patients when tamsulosin is co-administered with phosphodiesterase PDE5 inhibitors. Your email has been sent. If these drugs must be used together, do so with extreme caution. If the patient is also taking an alpha-blocker, the initial dose should be 2. Moderate Sapropterin acts as a cofactor in the synthesis of nitric oxide and may cause vasorelaxation. Delavirdine is expected to substantially increase vardenafil plasma concentrations and may result in vardenafil-related adverse events including hypotension, visual changes, and priapism. If vardenafil dose adjustments are made, re-adjust the dose upon completion of telaprevir treatment. According to the manufacturer, since iloperidone may prolong the QT interval, it should be avoided in combination with other agents also known to have this effect, such as vardenafil. Both therapeutic and supratherapeutic doses of vardenafil produce an increase in QTc interval e. The vardenafil orally disintegrating tablets provide increased exposure as compared to the regular tablets; therefore, do not use the orally disintegrating tablets with moderate or potent CYP3A4 inhibitors, such as clarithromycin Amyl Nitrite: This includes prescription and over-the-counter medicines, vitamins , and herbal products. The vardenafil orally disintegrating tablets ODTs provide increased exposure as compared to the regular tablets; therefore, use of the vardenafil ODTs with potent CYP3A4 inhibitors should be avoided. Major Concurrent use of vardenafil and levofloxacin should be avoided due to an increased risk for QT prolongation and torsade de pointes TdP. Major Ranolazine is associated with dose- and plasma concentration-related increases in the QTc interval. Dextromethorphan; Quinidine: In addition, there are postmarketing reports of torsade de pointes. Only use a PDE5 inhibitor in these individuals if the anticipated benefit outweighs the staxyn. It is recommended not to exceed a single 5-mg dose of vardenafil in a hour period when used in combination with moderate CYP3A4 inhibitors, such as grapefruit juice. Vardenafil orally disintegrating tablets ODT provide increased exposure as compared to the regular tablets; therefore, use with potent CYP3A4 inhibitors such as delavirdine is not recommended. If the use of nilotinib and vardenafil cannot be avoided, a stacyn doses reduction may be necessary; staxyb monitoring of the QT interval is recommended, staxyn doses. Explore Apps.

The vardenafil orally disintegrating tablets provide increased exposure as compared to the regular tablets; therefore, do not use the orally disintegrating tablets with moderate or potent CYP3A4 inhibitors, such as clarithromycin Amyl Nitrite: However, vardenafil has not been studied or administered to patients with bleeding disorders or significant active peptic ulcer disease. Ciprofloxacin has been associated with a possible risk for QT prolongation and TdP. Patients with severe hepatic impairment Child-Pugh class C: Major Concurrent use of phosphodiesterase PDE5 inhibitors, such as vardenafil, and alpha-blockers may lead to symptomatic hypotension in some patients. Major Vardenafil should be used cautiously and with close monitoring with goserelin. Both itraconazole and vardenafil have been associated with QT prolongation; coadministration may increase this risk. Vorinostat should be used with caution if given with vardenafil. In addition, haloperidol is a substrate for CYP2D6. There is a degree of cardiac risk associated with sexual activity; therefore, prescribers should evaluate the cardiovascular status of their patients prior to initiating any treatment for erectile dysfunction. Gastroesophageal reflux disease GERD , hiatal hernia. Advise patients to stop use of all phosphodiesterase 5 PDE5 inhibitors, including vardanafil, and seek medical attention for evaluation in the event of a sudden visual disturbance in 1 or both eyes. In addition, in vitro studies indicate that ranolazine and its metabolite are inhibitors of CYP3A isoenzymes. Major Avoid coadministration of lenvatinib with vardenafil due to the risk of QT prolongation. Major QT prolongation has been reported with panobinostat therapy in patients with multiple myeloma in a clinical trial; use of panobinostat with other agents that prolong the QT interval is not recommended. Postmarketing reports with PDE5 inhibitors have included cases of visual disturbances including retinal vein occlusion, visual field defects, reduced visual acuity, and loss of vision temporary or permanent. In addition, saquinavir boosted with ritonavir increases the QT and PR intervals in a dose-dependent fashion, which may increase the risk for serious arrhythmias such as torsades de pointes TdP. Vardenafil dosage reductions are required in patients taking moderate or potent CYP3A4 inhibitors. Drugs with a possible risk for QT prolongation and TdP that should be used cautiously with arsenic trioxide include vardenafil. Doses beta-agonists: This risk is generally higher at elevated drugs concentrations of phenothiazines. Patients should be stabilized on their alpha blocker therapy prior to starting vardenafil, or, if already receiving an optimum dose of vardenafil, the alpha blocker therapy should be started at the lowest possible doses. If coadministration is considered stwxyn, and the patient has known risk factors for cardiac disease or staxyn, then close monitoring is essential. Isoniazid, INH; Rifampin: Levomethadyl is contraindicated in combination with other agents that may prolong the QT interval. Vardenafil is administered orally. Coadministration of lopinavir; ritonavir Kaletra with these drugs is expected xoses substantially increase their plasma concentrations and may result in staxyn associated adverse events including hypotension, syncope, visual changes, and prolonged erection.